Biomarker: BMP-10

Histology type: endometrial carcinoma

Country: China

Region: Wuhan

Study type: retrospective study

Followed up time :

Subgroup 1 name : High expression

Subgroup 1 number: 63

Subgroup 2 name: Low expression

Subgroup 2 number: 80

Conclusion: BMP-10 can be adopted as a molecular marker for predicting the poor prognosis of patients with EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression(>3)

Expression elevation: According to the proportion of positive tumor cells, the staining was scored as follows: “0” points, the proportion was<10%; “1” point, the proportion was between 10 and 33%; “2” points, the proportion was between 34 and 66%; “3” points, the proportion was between 67 and 100%. The staining intensity was scored as follows: in at least fve diferent high-power felds, 0 points, negative; 1 point, weak; 2 points, moderate; 3 points, strong. The protein expression of BMP-10 was classifed semi-quantitatively according to the total score of the proportion of stained positive tumor cells and staining intensity. A score between 0 and 3 points indicated low expression (low expression group) and a score higher than 3 points indicated high expression (high expression group).

Statictics: cutoff<60;cutoff>60

Cohort age: 103;40

Subgroup 1 age: 44;19

Subgroup 2 age: 59;21

Funtion Uniprot: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

UniProt ID: O95393

UniProt Link: https://www.uniprot.org/uniprotkb/O95393/entry

Biological function from UniProt: #Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Detected in mammary epithelia (at protein level)

Subcellular UniProt: #Secreted

Recommended name: Bone morphogenetic protein 10

Gene name from HGNC: BMP10

AlphaFold DB: O95393

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O95393

Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines.

HPA link: https://www.proteinatlas.org/ENSG00000163217-BMP10

Tissue specificity RNA from HPA: Tissue enriched (heart muscle)

Single cell type specificity Not detected

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000163217-BMP10/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000163217-BMP10/pathology/endometrial+cancer

OMIM: 608748

OMIM link2: https://www.omim.org/entry/608748

HGNC ID: HGNC:20869

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20869