Biomarker: pEzrin

Histology type: endometrioid endometrial carcinoma

Country: Japan

Region: Wakayama City

Followed up time :

Subgroup 1 name : Negative

Subgroup 1 number: 31

Subgroup 2 name: Positive

Subgroup 2 number: 30

Conclusion: These results suggest that overexpression of podocalyxin and pEzrin may indicate a more aggressive phenotype; thus, evaluation of these proteins may be useful in prediction of disease progression in UEA cases.

Sample type : tissue

Sample method: immunohistochemisty

Expression pattern : expresssion

Expression elevation: Samples were considered positive for podocalyxin if cytoplasmic immunoreactivity was detected in at least 10% of the analysed cells, according to the mean immunopositive area 6SD (mean podocalyxin positive area 9.7%62.5%)

Funtion Uniprot: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

UniProt ID: P15311

UniProt Link: https://www.uniprot.org/uniprotkb/P15311/entry

Biological function from UniProt: #Cell shape

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

Subcellular UniProt: #Cell membrane #Cell projection #Cytoplasm #Cytoskeleton #Membrane

Alternative name from UniProt:

Activity regulation: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding.

Recommended name: Ezrin

Gene name from HGNC: EZR (VIL2)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P15311

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P15311

Developmental stage: Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.

HPA link: https://www.proteinatlas.org/ENSG00000092820-EZR

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic and membranous expression in most tissues.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000092820-EZR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000092820-EZR/pathology/endometrial+cancer

OMIM: 123900

OMIM link2: https://www.omim.org/entry/123900

HGNC ID: HGNC:12691

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12691