Basic information
Biomarker: pHH3
Histology type: Type II EC
Stage: high grade
Cohort characteristics
Country: China
Region: Chongqing
Followed up time :
Subgroup 1 name : pHH3 > median (36 mitoses/10 HPF) n
Subgroup 1 number: 48
Subgroup 2 name: <median (36 mitoses/10 HPF)
Subgroup 2 number: 51
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 113 | EC | 106 | simple hyperplasia without atypia | 7 |
Sample information
Conclusion: In endometrial cancer, pHH3 and survivin were strongly positive correlated and were both associated with type II and high-grade tumours. Increasing expression levels of pHH3 and survivin were associated with adverse prognostic factors.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : pHH3 > median
Expression elevation: The staining of pHH3 was recorded by counting positive cells in prophase, metaphase, anaphase, and telophase in selected areas with most positive nuclei, that is, ‘hot spots’ was determined. The total number of mitoses per 10 HPF (using × 400 magnification) was determined.pHH3⩽median(36 mitoses/10 HPF), pHH3>median(36 mitoses/10 HPF).
Disease information
Statictics: cutoff<70;cutoff>70
Cohort age: 59;40
Subgroup 1 age: 28;20
Subgroup 2 age: 31;20
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Immunohistochemical staining of phosphohistone-H3 (pHH3) in endometrial carcinoma.
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389407/figure/fig1/
