Biomarker: IPO13

Histology type: endometrial carcinoma

Country: Japan

Region: Osaka

Followed up time :

Conclusion: These results demonstrate an increased expression of IPO13 in endometriosis;endometrial carcinoma;which could be involved in the pathogenesis of endometriosis;endometrial carcinoma; IPO13 can serve as an endometrial progenitor/stem cell marker

Sample type : tissue

Sample method: immunohistochemistry;Fluorescence microscope;qPCR;Western blot

Expression pattern : increased expression

Expression elevation: Intensity was scored from 0 to 3: 0 (absent immunopositivity); 1 (low immunopositivity); 2 (moderate immunopositivity); 3 (intense immunopositivity). The ipo13-positive cells were counted and an average of 22 fields was observed for each tissue.

Statictics: Median;Range

Cohort age: 43;20–72

Funtion Uniprot: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13

UniProt ID: O94829

UniProt Link: https://www.uniprot.org/uniprotkb/O94829/entry

Biological function from UniProt: #Protein transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in fetal brain, heart, intestine and kidney.

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: Importin-13

Gene name from HGNC: IPO13 (IMP13, KIAA0724, RANBP13)

HPA class: Transporters

AlphaFold DB: O94829

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O94829

HPA link: https://www.proteinatlas.org/ENSG00000117408-IPO13

Tissue specificity RNA from HPA: Tissue enhanced (brain, skeletal muscle)

Tissue expression from HPA: Cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Late spermatids, Oligodendrocytes, Early spermatids)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable) and pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000117408-IPO13/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000117408-IPO13/pathology/endometrial+cancer

Expression figure legend: Representative immunohistochemical staining patterns of IPO13

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560734/figure/f1-medscimonit-18-6-cr361/

OMIM: 610411

OMIM link2: https://www.omim.org/entry/610411

HGNC ID: HGNC:16853

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16853