Biomarker: fascin

Histology type: endometrial carcinoma

Country: Turkey

Region: Zonguldak

Followed up time :

Subgroup 1 name : IHS ≤ 10

Subgroup 1 number: 27

Subgroup 2 name: IHS≥ 11

Subgroup 2 number: 7

Conclusion: Our findings suggest that fascin might be an independent prognostic indicator in the different steps of extracellular matrix invasion.

Sample type : tissue

Sample method: immunohistochemisty

Expression pattern : IHS ≥ 11

Expression elevation: The extent of positively stained epithelial cells was estimated and classified on a four-point scale as follows: no staining = 0%, 1 = 1%–10%, 2 = 11%–25%, 3 = 26%–50%, and 4 = 51%–100%. The intensity of the immunoexpression was categorised into three groups: weak (+1), moderate (+2), and strong (+3). A final IHS score was obtained by multiplying the score for extent and the score for intensity. Therefore, the combined immunoreactivity score ranged from 0 to 12. According to this, cases were categorised into three groups: 0 (absent), IHS ≤ 10, and IHS ≥ 11.

Funtion Uniprot: Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).

UniProt ID: Q16658

UniProt Link: FSCN1 - Fascin - Homo sapiens (Human) | UniProtKB | UniProt

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous.

Subcellular UniProt: #Cell junction #Cell projection #Cytoplasm #Cytoskeleton

Alternative name from UniProt:

Recommended name: Fascin

Gene name from HGNC: FSCN1 (FLJ38511, p55, SNL)

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: Q16658

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q16658

HPA link: https://www.proteinatlas.org/ENSG00000075618-FSCN1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression in cells in seminiferous tubules, glial cells, endothelial cells, fibroblasts and macrophages.

Single cell type specificity Monocytes - Immune response regulation (mainly)

Immune cell specificity: Immune cell enhanced (myeloid DC)

Subcellular summary HPA Located in Plasma membrane, Cytosol (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), lung cancer (unfavorable) and head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000075618-FSCN1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000075618-FSCN1/pathology/endometrial+cancer

Expression figure legend: Immunohistochemical staining for fascin.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407727/figure/F1/?report=objectonly

OMIM: 602689

OMIM link2: https://www.omim.org/entry/602689

HGNC ID: HGNC:11148

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11148