Biomarker: ERRγ

Histology type: endometrial carcinoma

Country: Japan

Region: Kyoto

Followed up time :

Subgroup 1 name : ERRFγPositive

Subgroup 1 number: 26

Subgroup 2 name: Negative

Subgroup 2 number: 57

Conclusion: The relationship between ERRF and ER> status could be a predictive marker for the treatment of endometrial cancer, which provides an impetus for the identification of ligands for the ERRF nuclear orphan receptor.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : ERRγ-positive/ERα-negative status

Expression elevation: The ERRF and ER> immunoreactivities were scored in more than 1000 cancer cells, and the percentage of positive cells was indicated as the labeling index.

Statictics: Mean (SD)

Subgroup 1 age: 58.4±1.9

Subgroup 2 age: 56.6 ± 1.6

Funtion Uniprot: Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle

UniProt ID: P62508

UniProt Link: https://www.uniprot.org/uniprotkb/P62508/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Miscellaneous: No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.

Recommended name: Estrogen-related receptor gamma

Gene name from HGNC: ESRRG (ERR-gamma, ERRg, NR3B3)

HPA class: FDA approved drug targets Nuclear receptors Transcription factors

AlphaFold DB: P62508

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P62508

Developmental stage: Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.

HPA link: https://www.proteinatlas.org/ENSG00000196482-ESRRG

Tissue specificity RNA from HPA: Tissue enhanced (brain, parathyroid gland, retina, stomach)

Tissue expression from HPA: Mainly cytoplasmic expression in few tissues.

Single cell type specificity Group enriched (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes, Syncytiotrophoblasts)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000196482-ESRRG/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000196482-ESRRG/pathology/endometrial+cancer

OMIM: 602969

OMIM link2: https://www.omim.org/entry/602969

HGNC ID: HGNC:3474

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3474