Basic information
Biomarker: HE4
Histology type: endometrial carcinoma
Cohort characteristics
Country: Italy
Region: Brescia
Study type: retrospective study
Followed up time :
Subgroup 1 name : EC
Subgroup 1 number: 193
Subgroup 2 name: NE control
Subgroup 2 number: 125
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 318 | EC | 193 | normal endometrium (NE) | 125 |
Sample information
Conclusion: HE4 significant correlation with decreased Overall Survival, Disease Free Survival and Progression Free Survival suggests its potential role as a novel prognostic marker for endometrial cancer.
Sample type : serum
Sample method: quantitative chemiluminescent microparticle immunoassays
Expression pattern : cut-off = 51 p M
Disease information
Statictics: Median;Range
Cohort age: 66;28 – 92
Subgroup 1 age: 66;28 – 92
Subgroup 2 age: 61;35 – 76
Related information
Funtion Uniprot: Broad range protease inhibitor.
UniProt ID: Q14508
UniProt Link: https://www.uniprot.org/uniprotkb/Q14508/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: WAP four-disulfide core domain protein 2
Gene name from HGNC: WFDC2 (dJ461P17.6, EDDM4, HE4, WAP5)
HPA class: Cancer-related genes
AlphaFold DB: Q14508
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14508
HPA link: https://www.proteinatlas.org/ENSG00000101443-WFDC2
Tissue specificity RNA from HPA: Tissue enhanced (cervix, salivary gland)
Tissue expression from HPA: Cytoplasmic expression in selected tissues.
Single cell type specificity Cell type enhanced (Club cells, Glandular and luminal cells, Basal respiratory cells, Urothelial cells, Endometrial ciliated cells, Respiratory ciliated cells, Collecting duct cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Secreted
Cancer prognostic summary HPA Prognostic marker in glioma (unfavorable) and renal cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000101443-WFDC2//pathology/endometrial+cancer
OMIM: 617548
OMIM link2: https://www.omim.org/entry/617548
HGNC ID: HGNC:15939
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939
