Biomarker: Wnt7a

Histology type: endometrial carcinoma

Country: China

Region: Harbin

Followed up time :

Subgroup 1 name : negative

Subgroup 1 number: 89

Subgroup 2 name: positive

Subgroup 2 number: 156

Conclusion: Overexpression of Wnt7a may contribute to the progression of endometrial cancer and thus may serve as a new biomarker to predict the prognosis of endometrial cancer.

Sample type : tissue

Sample method: Immunohistochemistry

Expression pattern : Overexpression(≥4)

Expression elevation: the final score (0-16) was calculated multiplying the positive proportion score by staining intensity score

Statictics: cutoff<60;cutoff>60

Cohort age: 127;117

Subgroup 1 age: 52;37

Subgroup 2 age: 76;80

Funtion Uniprot: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).

UniProt ID: O00755

UniProt Link: https://www.uniprot.org/uniprotkb/O00755/entry

Biological function from UniProt: #Wnt signaling pathway

Molecular function from UniProt:

Tissue specificity from UniProt: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.

Subcellular UniProt: #Extracellular matrix #Secreted

Recommended name: Protein Wnt-7a

Gene name from HGNC: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

HPA class: Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: O00755

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O00755

HPA link: https://www.proteinatlas.org/ENSG00000154764-WNT7A

Tissue specificity RNA from HPA: Tissue enhanced (brain, gallbladder, placenta)

Tissue expression from HPA: plasma protein.

Single cell type specificity Group enriched (Syncytiotrophoblasts, Extravillous trophoblasts, Pancreatic endocrine cells, Cytotrophoblasts)

Immune cell specificity: Group enriched (memory CD4 T-cell, naive CD4 T-cell)

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable) and endometrial cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000154764-WNT7A/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000154764-WNT7A/pathology/endometrial+cancer

Phenotype ID: 276820;228930;

Disease: Limb pelvis hypoplasia aplasia syndrome (LPHAS) ;Fuhrmann syndrome (FUHRS);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 601570

OMIM link1: https://www.omim.org/entry/276820;https://www.omim.org/entry/228930;

OMIM link2: https://www.omim.org/entry/601570

HGNC ID: HGNC:12786

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12786