Basic information
Biomarker: periostin
Histology type: endometrial carcinoma
Stage: early stage
Cohort characteristics
Country: Turkey
Region: Malatya
Study type: prospective cross-sectional study
Followed up time :
Subgroup 1 name : study
Subgroup 1 number: 38
Subgroup 2 name: control
Subgroup 2 number: 21
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 59 | early-stage endometrial cancer | 38 | benign endometrial pathologies | 21 |
Sample information
Conclusion: Serum periostin levels were significantly higher in women with endometrial cancer than in those without cancer，this results may help identify new markers for diagnosing endometrial cancer.
Sample type : serum
Sample method: immunoassay analysis
Expression pattern : high level
Expression elevation: cutoff=11.04 ng/mL
Disease information
Statictics: Mean ;Range
Subgroup 1 age: 58.5;38–81
Subgroup 2 age: 46;38–73
Related information
Funtion Uniprot: Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).
UniProt ID: Q15063
UniProt Link: https://www.uniprot.org/uniprotkb/Q15063/entry
Biological function from UniProt: Cell adhesion
Molecular function from UniProt:
Tissue specificity from UniProt: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
Subcellular UniProt: #Extracellular matrix #Golgi apparatus #Secreted
Alternative name from UniProt:
Recommended name: Periostin
Gene name from HGNC: POSTN (OSF-2, periostin, PN)
HPA class: Cancer-related genes Plasma proteins
AlphaFold DB: Q15063
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q15063
HPA link: https://www.proteinatlas.org/ENSG00000133110-POSTN
Tissue specificity RNA from HPA: Tissue enhanced (skin, stomach)
Tissue expression from HPA: Distinct expression in extracellular matrix.
Single cell type specificity Cell type enhanced (Basal keratinocytes, Fibroblasts, Breast myoepithelial cells, Smooth muscle cells, Endothelial cells)
Subcellular summary HPA Located in Nucleoplasm, Golgi apparatus;
Pathology link: https://www.proteinatlas.org/ENSG00000133110-POSTN/tissue
OMIM: 608777
OMIM link2: https://www.omim.org/entry/608777
HGNC ID: HGNC:16953
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16953
