Biomarker: Visfatin

Histology type: endometrial carcinoma

Stage: high risk

Country: China

Region: Tianjin

Followed up time :

Subgroup 1 name : Tissue

Subgroup 1 number: 114

Subgroup 2 name: Serum

Subgroup 2 number: 70

Conclusion: Visfatin is a potential serum biomarker and prognostic factor for EC that may indicate high risk for EC and EC progression. It may also be a novel potential therapeutic target for EC.

Sample type : serum

Sample method: ELISA/immunohistochemistry

Expression pattern : Visfatin expression was determined by adding the positive staining percentage score and intensity score: 0, negative expression; ≤3, low expression; and >3, high expression

Expression elevation: Visfatin expression was determined by adding the positive staining percentage score and intensity score: 0, negative expression; ≤3, low expression; and >3, high expression)

Funtion Uniprot: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

UniProt ID: P43490

UniProt Link: https://www.uniprot.org/uniprotkb/P43490/entry

Biological function from UniProt: #Biological rhythms #Pyridine nucleotide biosynthesis

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Subcellular UniProt: #Cytoplasm #Nucleus #Secreted

Alternative name from UniProt:

Catalytic activity: beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamideBy Similarity This reaction proceeds in the backward direction.

Activity regulation: Inhibited by FK866. FK866 competes for the same binding site as nicotinamide, but due to its very low dissociation rate, it is essentially an irreversible inhibitor.

Recommended name: Nicotinamide phosphoribosyltransferase

Gene name from HGNC: NAMPT (PBEF, PBEF1)

HPA class: Cancer-related genes Enzymes Metabolic proteins Plasma proteins

AlphaFold DB: P43490

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P43490

HPA link: https://www.proteinatlas.org/ENSG00000105835-NAMPT

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General cytoplasmic expression, highest abundance in lymphoid tissues and gastrointestinal tract. Positivity in plasma.

Single cell type specificity Cell type enhanced (Langerhans cells, Macrophages, Hepatocytes)

Immune cell specificity: Immune cell enriched (neutrophil)

Subcellular summary HPA Located in Nuclear speckles, Cell Junctions

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), pancreatic cancer (unfavorable), cervical cancer (unfavorable) and head and neck cancer (unfavorable)

Pathology endo: https://www.proteinatlas.org/ENSG00000105835-NAMPT/pathology/endometrial+cancer

OMIM: 608764

OMIM link2: https://www.omim.org/entry/608764

HGNC ID: HGNC:30092

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30092