Basic information
Biomarker: CTR1
Histology type: endometrial carcinoma
Stage: stage III
Cohort characteristics
Country: Japan
Region: Yokohama
Followed up time :
Subgroup 1 name : low
Subgroup 1 number: 17
Subgroup 2 name: high
Subgroup 2 number: 30
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 47 | EC | 47 |
Sample information
Conclusion: Our findings suggest that combined OATP1B3/CTR1 expression is a possible predictive/prognostic factor for a good outcome in stage III endometrial cancer patients treated with adjuvant TC chemotherapy.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : high expression( 4–6)
Expression elevation: Classified the scores of 0–4 for CTR1 as low expression levels and the scores of 5–6 for CTR1 as high expression levels.
Disease information
Statictics: cutoff<55;cutoff>55
Cohort age: 17;30
Subgroup 1 age: 5;12
Subgroup 2 age: 12;18
Related information
Funtion Uniprot: High-affinity, saturable copper transporter involved in dietary copper uptake.
UniProt ID: O15431
UniProt Link: https://www.uniprot.org/uniprotkb/O15431/entry
Biological function from UniProt: #Copper transport #Ion transport #Transport
Molecular function from UniProt:
Subcellular UniProt: #Cell membrane #Membrane
Alternative name from UniProt:
Recommended name: High affinity copper uptake protein 1
Gene name from HGNC: SLC31A1 (COPT1, CTR1, hCTR1)
HPA class: Metabolic proteins Transporters
AlphaFold DB: O15431
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O15431
HPA link: https://www.proteinatlas.org/ENSG00000136868-SLC31A1
Tissue specificity RNA from HPA: Tissue enhanced (liver)
Tissue expression from HPA: Cytoplasmic expression in most tissues at variable levels.
Single cell type specificity Cell type enhanced (Hepatocytes)
Immune cell specificity: Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, myeloid DC, neutrophil)
Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and thyroid cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000136868-SLC31A1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000136868-SLC31A1/pathology/endometrial+cancer
OMIM: 603085
OMIM link2: https://www.omim.org/entry/603085
HGNC ID: HGNC:11016
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11016
