Biomarker: OATP1B3

Histology type: endometrial carcinoma

Stage: stage III

Country: Japan

Region: Yokohama

Followed up time :

Subgroup 1 name : low

Subgroup 1 number: 40

Subgroup 2 name: high

Subgroup 2 number: 7

Conclusion: Our findings suggest that combined OATP1B3/CTR1 expression is a possible predictive/prognostic factor for a good outcome in stage III endometrial cancer patients treated with adjuvant TC chemotherapy.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression( 4–6)

Expression elevation: Classified the scores of 0–3 for OATP1B3 as low expression levels and the scores of 4–6 for OATP1B3 for CTR1 as high expression levels.

Statictics: cutoff<55;cutoff>55

Cohort age: 17;55

Subgroup 1 age: 15;25

Subgroup 2 age: 2;5

Funtion Uniprot: Mediates the Na+-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

UniProt ID: Q9NPD5

UniProt Link: https://www.uniprot.org/uniprotkb/Q9NPD5/entry

Biological function from UniProt: #Ion transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Solute carrier organic anion transporter family member 1B3

Gene name from HGNC: SLCO1B3 (OATP1B3, OATP8, SLC21A8)

HPA class: Disease related genes Human disease related genes Metabolic proteins Potential drug targets Transporters

AlphaFold DB: Q9NPD5

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NPD5

HPA link: https://www.proteinatlas.org/ENSG00000111700-SLCO1B3

Tissue specificity RNA from HPA: Tissue enriched (liver)

Tissue expression from HPA: Selective membranous expression in liver along with extracellular positivity in liver.

Single cell type specificity Cell type enriched (Hepatocytes)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000111700-SLCO1B3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000111700-SLCO1B3/pathology/endometrial+cancer

Phenotype ID: 237450

Disease: Hyperbilirubinemia, Rotor type (HBLRR)

Note1: The disease is caused by variants affecting the gene represented in this entry

Note2: A number sign (#) is used with this entry because Rotor type hyperbilirubinemia (HBLRR) is caused by digenic inheritance of homozygous mutations in the SLCO1B1 (604843) and SLCO1B3 (605495) genes, which are located near each other on chromosome 12p.

OMIM: 605495; 237450

OMIM link1: https://www.omim.org/entry/237450

OMIM link2: https://www.omim.org/entry/605495;https://www.omim.org/entry/237450;

Phenotype: HYPERBILIRUBINEMIA, ROTOR TYPE; HBLRR

HGNC ID: HGNC:10961

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10961