Basic information
Biomarker: PPP2R1B
Histology type: endometrial serous carcinomas
Stage: risk
Cohort characteristics
Country: USA
Region: Rochester, Minnesota
Study type: retrospective study
Followed up time :
Subgroup 1 name : USC
Subgroup 1 number: 36
Subgroup 2 name: TCGA data set USC
Subgroup 2 number: 109
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 145 | serous histology | 36 | TCGA data set USC | 109 |
Sample information
Conclusion: Higher cytoplasmic expression of PPP2R1B (Protein Phosphatase 2 A, Scaffold Subunit Abeta) were each associated with a decreased risk of progression, after adjusting for stage
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : higher cytoplasmic expression
Expression elevation: Expression was evaluated by considering the percentage of cells exhibiting immunoreaction, as well as the localization of signalling (nuclear and/or cytoplasmic).
Disease information
Statictics: Mean (SD);Range
Cohort age: 72.2± 9.0;54.8–89.8
Subgroup 1 age: 58.5 ;38–81
Subgroup 2 age: 46;38–73
Related information
Funtion Uniprot: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
UniProt ID: P30154
UniProt Link: https://www.uniprot.org/uniprotkb/P30154/entry
Molecular function from UniProt:
Alternative name from UniProt:
Recommended name: PP2A subunit A isoform PR65-beta PP2A subunit A isoform R1-beta
Gene name from HGNC: PPP2R1B (PP2A-Abeta, PR65B)
HPA class: Metabolic proteins
AlphaFold DB: P30154
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P30154
HPA link: https://www.proteinatlas.org/ENSG00000137713-PPP2R1B
Tissue specificity RNA from HPA: Tissue enhanced (liver)
Tissue expression from HPA: Cytoplasmic expression in most tissues.
Single cell type specificity Cell type enhanced (Early spermatids, Late spermatids, Spermatocytes)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Plasma membrane, Cytosol
Cancer prognostic summary HPA Prognostic marker in liver cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000137713-PPP2R1B/tissue
Expression figure legend: Immunohistochemistry-based protein profiling of uterine serous carcinomas (UCS) patients
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076151/figure/Fig2/
Survival figure legend: Kaplan–Meier curves for progression-free survival (a) and overall survival (b), according to stage
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076151/figure/Fig1/
OMIM: 603113
OMIM link2: https://www.omim.org/entry/603113
HGNC ID: HGNC:9303
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9303
