Biomarker: albumin

Histology type: endometrial carcinoma

Country: Austria

Region: Vienna

Followed up time :

Conclusion: Pre-treatment serum albumin is a novel and independent prognostic parameter for disease-free and progression-free survival in patients with endometrial cancer.

Sample type : serum

Expression pattern : pre-treatment serum albumin ≤42.1 mg/dl

Expression elevation: Serum albumin concentrations between 34 and 48 g/l were defined as normal

Funtion Uniprot: Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).

UniProt ID: P02768

UniProt Link: https://www.uniprot.org/uniprotkb/P02768/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Plasma.

Subcellular UniProt: #Secreted

Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow.

Recommended name: Albumin

Gene name from HGNC: ALB

HPA class: Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Metabolic proteins Plasma proteins

AlphaFold DB: P02768

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P02768

HPA link: https://www.proteinatlas.org/ENSG00000163631-ALB

Tissue specificity RNA from HPA: Tissue enriched (liver)

Tissue expression from HPA: Positivity in plasma and extracellular matrix.

Single cell type specificity Cell type enriched (Hepatocytes)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Endoplasmic reticulum, Golgi apparatus

Cancer prognostic summary HPA Prognostic marker in stomach cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000163631-ALB/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000163631-ALB/pathology/endometrial+cancer

Phenotype ID: 616000;616000;

Disease: Hyperthyroxinemia, familial dysalbuminemic (FDAH);Analbuminemia (ANALBA);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 103600

OMIM link1: https://www.omim.org/entry/615999;https://www.omim.org/entry/616000;

OMIM link2: https://www.omim.org/entry/103600

HGNC ID: HGNC:399

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:399