Biomarker: Pin1

Histology type: endometrial carcinoma

Country: China

Region: Hunan

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 12

Subgroup 2 name: negative

Subgroup 2 number: 18

Conclusion: Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpress

Funtion Uniprot: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383).

UniProt ID: Q13526

UniProt Link: https://www.uniprot.org/uniprotkb/Q13526/entry

Biological function from UniProt: #Cell cycle

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in immune cells in the lung (at protein level) (PubMed:29686383). The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Catalytic activity: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Recommended name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Gene name from HGNC: PIN1 (dod)

HPA class: Cancer-related genes Enzymes Metabolic proteins

AlphaFold DB: Q13526

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q13526

HPA link: https://www.proteinatlas.org/ENSG00000127445-PIN1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear and cytoplasmic expression in several tissues with highest levels in neuronal cells of CNS.

Single cell type specificity Cell type enhanced (Late spermatids)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Cytosol

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000127445-PIN1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000127445-PIN1/pathology/endometrial+cancer

OMIM: 601052

OMIM link2: https://www.omim.org/entry/601052

HGNC ID: HGNC:8988

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8988