Basic information
Biomarker: napsin A
Histology type: endometrial clear cell carcinoma
Cohort characteristics
Study type: Multicenter Study
Followed up time :
Subgroup 1 name : ≥1+ immunoreactivity in CCC
Subgroup 1 number: 43
Subgroup 2 name: <1 immunoreactivity in CCC
Subgroup 2 number: 6
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 143 | CCC | 77 | EEC | 49 | serous carcinomas. | 17 |
Sample information
Conclusion: napsin A is a sensitive and specific biomarker of the clear cell histotype in endometrial carcinomas and accordingly may have diagnostic utility in their histotyping.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : ≥1+
Expression elevation: The percentage of immunoreactive tumor epithelial cells in the examined tissue irrespective of staining intensity: 0, 0% positive; 1+, 1% to 25% positive; 2+, 26% to 49% positive; 3+, Z50% positive
Disease information
Related information
Funtion Uniprot: May be involved in processing of pneumocyte surfactant precursors.
UniProt ID: O96009
UniProt Link: https://www.uniprot.org/uniprotkb/O96009/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Napsin-A
Gene name from HGNC: NAPSA (KAP, Kdap, NAP1, NAPA)
HPA class: Enzymes Metabolic proteins Plasma proteins
AlphaFold DB: O96009
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O96009
HPA link: https://www.proteinatlas.org/ENSG00000131400-NAPSA
Tissue specificity RNA from HPA: Tissue enriched (lung)
Tissue expression from HPA: Selective cytoplasmic expression in lung and kidney.
Single cell type specificity Cell type enriched (Alveolar cells type 2)
Immune cell specificity: Immune cell enhanced (plasmacytoid DC)
Subcellular summary HPA Located in Nucleoplasm
Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000131400-NAPSA/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000131400-NAPSA/pathology/endometrial+cancer
OMIM: 605631
OMIM link2: https://www.omim.org/entry/605631
HGNC ID: HGNC:13395
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13395
