Biomarker: URI

Histology type: endometrioid endometrial carcinoma

Stage: high grade

Country: China

Region: Jiangsu

Followed up time :

Subgroup 1 name : G1

Subgroup 1 number: 3

Subgroup 2 name: G2;G3

Subgroup 2 number: 17;7

Conclusion: The higher level of URI/RMP expression in high-grade endometrioid adenocarcinomas compared to tissues of adjacent endometrium or gland suggests a diagnostic and possibly, a prognostic value of URI/RMP in endometrioid adenocarcinoma.

Sample type : tissue

Sample method: immunohistochemistry,Microscope and image analysis

Expression pattern : higher level of URI/RMP expression

Expression elevation: The mean densitometry of the digital image (×400) is designated as representative URI/RMP staining intensity (indicating relative URI/RMP expression level).The mean densitometry of the digital image (×400) is designated as representative URI/RMP staining intensity (indicating relative URI/RMP expression level).

Statictics: Average

Subgroup 1 age: 60

Subgroup 2 age: 62.5;56

Funtion Uniprot: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

UniProt ID: O94763

UniProt Link: https://www.uniprot.org/uniprotkb/O94763/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells

Subcellular UniProt: #Cell projection #Cytoplasm #Mitochondrion #Nucleus

Alternative name from UniProt:

Recommended name: Unconventional prefoldin RPB5 interactor 1

Gene name from HGNC: URI1 (C19orf2, FLJ10575, NNX3, PPP1R19, RMP, URI)

AlphaFold DB: O94763

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O94763

HPA link: https://www.proteinatlas.org/ENSG00000105176-URI1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Cytosol (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000105176-URI1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000105176-URI1/pathology/endometrial+cancer

Expression figure legend: URI/RMP IHC in Representative Grade-II and Adjacent Endometria.$URI/RMP IHC in Representative Grade III and Adjacent Endometria

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816808/figure/fig03/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816808/figure/fig04/

OMIM: 603494

OMIM link2: https://www.omim.org/entry/603494

HGNC ID: HGNC:13236

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13236