Basic information
Biomarker: maspin
Histology type: benign tumor
Cohort characteristics
Country: Italy
Region: Padova
Followed up time :
Subgroup 1 name : endometrial hyperplasia
Subgroup 1 number: 75
Subgroup 2 name: Normal control
Subgroup 2 number: 23
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 212 | EEC | 114 | endometrial hyperplasia | 75 | normal control | 23 |
Sample information
Conclusion: Maspin positivity in endometrial hyperplasia could be used to identify pseudo-atypical hyperplasia and could be considered a potentially useful prognostic parameter in those cases in which adenocarcinomas are well differentiated.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : expression
Disease information
Related information
Funtion Uniprot: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
UniProt ID: P36952
UniProt Link: https://www.uniprot.org/uniprotkb/P36952/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Normal mammary epithelial cells.
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Serpin B5
Gene name from HGNC: SERPINB5 (maspin, PI5)
HPA class: Disease related genes
AlphaFold DB: P36952
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P36952
HPA link: https://www.proteinatlas.org/ENSG00000206075-SERPINB5
Tissue specificity RNA from HPA: Tissue enhanced (esophagus, skin)
Tissue expression from HPA: Cytoplasmic expression with varying intensity in most tissues, most abundant in squamous epithelia and the gastrointestinal tract.
Single cell type specificity Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Urothelial cells, Squamous epithelial cells, Basal prostatic cells, Basal respiratory cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Located in Vesicles
Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable) and lung cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000206075-SERPINB5/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000206075-SERPINB5/pathology/endometrial+cancer
OMIM: 154790
OMIM link2: https://www.omim.org/entry/154790
HGNC ID: HGNC:8949
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8949
