Biomarker: GdA

Histology type: endometrial carcinoma

Country: Germany

Region: Munich

Followed up time :

Subgroup 1 name : Low

Subgroup 1 number: 82

Subgroup 2 name: Intermediate;high

Subgroup 2 number: 181;26

Conclusion: Immunosuppressive Glycodelin A is an independent marker for poor prognosis in endometrial cancer.Gd and GdA are commonly expressed in endometrial cancer tissue and seem to be of relevance in tumourigenesis. They differ not only in glycosylation but also in their biological activity, since only GdA holds prognostic significance for a poor overall survival in endometrial cancer patients. This finding might be explained by GdAs immunosuppressive capacity.

Sample type : tissue

Sample method: immunohistochemistry,In situ hybridization

Expression pattern : high positivity

Expression elevation: The IRS, ranging from 0 to 12, multiplicates staining intensity (graded as 0 = no, 1 = weak, 2 = moderate, and 3 = strong staining) and the percentage of positively stained cells (0 = no, 1 ≤ 10%, 2 = 11–50%, 3 = 51–80% and 4 ≥ 81% cells). Intermediate positivity was set as median IRS ± one IRS unit, while low to negative immunoreactivity was assumed for IRS ≤ median IRS - two IRS units and high positivity was attributed for IRS ≥ median IRS + two IRS units.

Statictics: Mean (SD);Range

Cohort age: 65.1 ± 0.6;35.6-88.1

Funtion Uniprot: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

UniProt ID: Q9Y2T3

UniProt Link: https://www.uniprot.org/uniprotkb/Q9Y2T3/entry

Molecular function from UniProt:

Alternative name from UniProt:

Catalytic activity: guanine + H+ + H2O = NH4+ + xanthine This reaction proceeds in the forward direction.

Recommended name: Guanine deaminase

Gene name from HGNC: GDA

HPA class: Candidate cardiovascular disease genes

AlphaFold DB: Q9Y2T3

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9Y2T3

HPA link: https://www.proteinatlas.org/ENSG00000119125-GDA

Tissue specificity RNA from HPA: Tissue enhanced (brain, intestine, kidney, liver)

Tissue expression from HPA: Cytoplasmic expression in the small intestine, hepatocytes, pancreatic islet cells and kidney tubules.

Single cell type specificity Cell type enhanced (Proximal enterocytes, Glandular and luminal cells, Endometrial ciliated cells, Excitatory neurons, Proximal tubular cells, Paneth cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000119125-GDA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000119125-GDA/pathology/endometrial+cancer

Expression figure legend: Gd mRNA (PAEP) was detected in endometrial cancer tissue by in situ hybridization$ Glycodelin and Glycodelin A protein was detected in endometrial cancer tissue by immunohistochemistry.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898404/figure/F1/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898404/figure/F2/

Survival figure legend: Kaplan Meier survival analyses were performed for Glycodelin and Glycodelin A in endometrial cancer patients.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898404/figure/F4/

OMIM: 139260

OMIM link2: https://www.omim.org/entry/139260

HGNC ID: HGNC:4212

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4212