Biomarker: stathmin

Histology type: endometrial carcinoma

Country: Norway

Region: Bergen

Study type: prospective study

Followed up time :

Subgroup 1 name : Paclitaxel

Subgroup 1 number: 22

Subgroup 2 name: Other treatment

Subgroup 2 number: 56

Conclusion: This study suggests, supported by both preclinical and clinical data, that stathmin could be a predictive biomarker for response to paclitaxel treatment in endometrial cancer. Re-assessment of stathmin level in metastatic lesions prior to treatment start may be relevant. Also, validation in a randomized clinical trial will be important.

Sample type : tissue

Sample method: immunohistochemistry and western blot

Expression pattern : expression( score 9)

Expression elevation: A semiquantitative grading system incorporating staining intensity (score 0–3) and area of tumor with positive staining (0, no staining;1, <10%; 2, 10%–50%; and 3, >50% of tumor cells) was applied. Staining index was calculated as the product of staining intensity and staining area, range 0–9.High protein level was defined as the upper quartile, score 9.

Statictics: cutoff<66;cutoff>66

Cohort age: 38;40

Subgroup 1 age: 15;7

Subgroup 2 age: 23;33

Funtion Uniprot: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

UniProt ID: P16949

UniProt Link: https://www.uniprot.org/uniprotkb/P16949/entry

Biological function from UniProt: #Differentiation #Neurogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Subcellular UniProt: #Cytoplasm #Cytoskeleton #Microtubule

Alternative name from UniProt:

Recommended name: Stathmin

Gene name from HGNC: STMN1 (C1orf215, FLJ32206, Lag, LAP18, OP18, PP17, PP19, PR22, SMN)

HPA class: Cancer-related genes

AlphaFold DB: P16949

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P16949

Induction: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level)

HPA link: https://www.proteinatlas.org/ENSG00000117632-STMN1

Tissue specificity RNA from HPA: Tissue enhanced (brain, lymphoid tissue)

Tissue expression from HPA: Cytoplasmic expression in most tissues, including brain and lymphoid tissues

Single cell type specificity Cell type enhanced (Late spermatids)

Immune cell specificity: Immune cell enhanced (plasmacytoid DC)

Subcellular summary HPA Located in Cytosol (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000117632-STMN1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000117632-STMN1/pathology/endometrial+cancer

Expression figure legend: Stathmin protein expression in relation to clinical parameters.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934991/figure/pone-0090141-g004/

Survival figure legend: Disease specific survival after primary treatment for endometrial carcinoma patients (Kaplan-Meier curves) related to stathmin protein expression by IHC in primary tumor.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934991/figure/pone-0090141-g005/

OMIM: 151442

OMIM link2: https://www.omim.org/entry/151442

HGNC ID: HGNC:6510

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6510