Biomarker: TNFAIP8

Histology type: endometrial carcinoma

Country: China

Region: Harbin

Followed up time :

Subgroup 1 name : Low

Subgroup 1 number: 116

Subgroup 2 name: High

Subgroup 2 number: 109

Conclusion: These findings suggested that TNFAIP8 may be used as a prognostic marker for the recurrence of EC, and its promotion of the proliferation and metastasis in EC may be due to its mediation of Ki-67 and MMP9.

Sample type : tissue

Sample method: immunohistochemistry and western blot

Expression pattern : overexpression(4–7)

Expression elevation: TNFAIP8 and MMP9 protein expression was scored by evaluating the extent and intensity of staining as previously described. The extent of the staining, defined as the percentage of positive staining areas of tumor cells, was scored as follows: 0, 0 %; 1, 0–10 %; 2, 11–50 %; 3, 51–70 %; and 4, ≥71 %. The staining intensity was scored as follows: 0, negative staining; 1, weak staining; 2, moderate staining; and 3, intense staining. The sum of the staining extent and intensity scores was calculated as the final staining score (0–7). For statistical analysis, the final staining scores of 0–3 and 4–7 were respectively considered to be low and high expression, respectively

Statictics: cutoff<55;cutoff>55

Cohort age: 115;110

Subgroup 1 age: 56;59

Subgroup 2 age: 60;60

Funtion Uniprot: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

UniProt ID: O95379

UniProt Link: https://www.uniprot.org/uniprotkb/O95379/entry

Biological function from UniProt: #Apoptosis

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Subcellular UniProt: #Cytoplasm

Alternative name from UniProt:

Recommended name: Tumor necrosis factor alpha-induced protein 8

Gene name from HGNC: TNFAIP8 (GG2-1, MDC-3.13, SCC-S2)

AlphaFold DB: O95379

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O95379

Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.

Developmental stage: Expressed at high levels in the fetal liver, lung and kidney.

HPA link: https://www.proteinatlas.org/ENSG00000145779-TNFAIP8

Tissue specificity RNA from HPA: Tissue enhanced (lymphoid tissue)

Tissue expression from HPA: Cytoplasmic expression in lymphoid tissues and in the gastrointestinal tract.

Single cell type specificity Cell type enhanced (Langerhans cells, Syncytiotrophoblasts, granulocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm (Single cell variability, CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in breast cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000145779-TNFAIP8/pathology

OMIM: 612111

OMIM link2: https://www.omim.org/entry/612111

HGNC ID: HGNC:17260

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17260