Biomarker: HDGF

Histology type: endometrial carcinoma

Country: China

Region: Guangzhou

Followed up time :

Subgroup 1 name : High

Subgroup 1 number: 31

Subgroup 2 name: Low

Subgroup 2 number: 91

Conclusion: Our results suggest that high nuclear expression of HDGF is a potential unfavorable factor for the progression and prognosis of EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high nuclear expression(tumors with 80% or more nuclear staining were regarded as high expression, )

Expression elevation: The staining results were defined based on the percentage of positive nuclei staining. Tumors with 80% or more nuclear staining were regarded as high expression, and less than 80% were regarded as low expression.

Statictics: Range

Cohort age: 30- 82

Funtion Uniprot: Isoform 1 Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).4 Publications Isoform 2 Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719).1 Publication Isoform 3 Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).1 Publication

UniProt ID: P51858

UniProt Link: https://www.uniprot.org/uniprotkb/P51858/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous.

Subcellular UniProt: #Cytoplasm #Nucleus #Secreted

Alternative name from UniProt:

Recommended name: Hepatoma-derived growth factor

Gene name from HGNC: HDGF (HMG1L2)

HPA class: Plasma proteins

AlphaFold DB: P51858

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P51858

HPA link: https://www.proteinatlas.org/ENSG00000143321-HDGF

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Distinct nuclear expression in all tissues.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable), endometrial cancer (unfavorable) and ovarian cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000143321-HDGF/pathology

Expression figure legend: HDGF protein is expressed in the nuclei of malignant epithelial cells for EC samples (original magnification: ×400).

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947826/figure/fig1/

Survival figure legend: Nuclear expression of HDGF protein predicts EC patients' overall survival time.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947826/figure/fig2/

HGNC ID: HGNC:4856

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4856