Biomarker: Rictor

Histology type: endometrial carcinoma

Country: China

Region: Shangha

Followed up time :

Conclusion: Rictor is an independent prognostic factor for endometrial carcinoma

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression（ score 1-3）

Expression elevation: Conducted scoring in the light of the staining intensity and percentage of positive-staining cells. 0-5% scored 0; 6-35% scored 1; 36-70% scored 2; more than 70% scored 3. We designated the final score as negative or positive expression group as follows: score 0, negative expression, score 1-3, positive expression.

Funtion Uniprot: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

UniProt ID: Q6R327

UniProt Link: https://www.uniprot.org/uniprotkb/Q6R327/entry

Biological function from UniProt: #Host-virus interaction

Molecular function from UniProt:

Alternative name from UniProt:

Recommended name: Rapamycin-insensitive companion of mTOR

Gene name from HGNC: RICTOR (AVO3, KIAA1999, MGC39830, PIA)

AlphaFold DB: Q6R327

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q6R327

HPA link: https://www.proteinatlas.org/ENSG00000164327-RICTOR

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous cytoplasmic expression in most tissues.

Single cell type specificity Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)

Immune cell specificity: Immune cell enhanced (neutrophil)

Subcellular summary HPA Located in Mitochondria

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000164327-RICTOR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000164327-RICTOR/pathology/endometrial+cancer

Expression figure legend: Rictor mRNA expression in 30 fresh EC tissue samples and 17 fresh normal endometrial tissues using real-time quantitative RT-

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig01/

Survival figure legend: Univariate analyses of factors were associated with OS in test and validation cohorts by Kaplan-Meier method and log-rank test$ Prognostic significance of Rictor expression was assessed for all 249 samples separated according to pathological type, grade, vascular invasion and lymphatic metastasis by Kaplan-Meier method and log-rank test.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig02/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig03/

OMIM: 609022

OMIM link2: https://www.omim.org/entry/609022

HGNC ID: HGNC:28611

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28611