Biomarker: CRHR1

Histology type: endometrial carcinoma

Country: Japan

Region: Sendai

Followed up time :

Subgroup 1 name : Positive

Subgroup 1 number: 13

Subgroup 2 name: Negative

Subgroup 2 number: 74

Conclusion: These results suggest that intratumoral CRH-CRHR1 signaling plays an important role in the progression of endometrial carcinoma and that CRHR1 is a potent prognostic factor in patients with this disease.

Sample type : tissue

Sample method: Immunohistochemistry

Expression pattern : CRHR1 nagetive

Expression elevation: When CRH, CRHR1, and CRHR2 immunoreactivity was detected in the cytoplasm of the endometrial carcinoma cells, cases with more than 10% positive carcinoma cells were considered positive for CRH, CRHR1, and CRHR2 because 10% is frequently used as the cutoff for the evaluation of cytoplasmic immunostaining.

Statictics: Median

Subgroup 1 age: 56

Subgroup 2 age: 56

Funtion Uniprot: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli

UniProt ID: P34998

UniProt Link: https://www.uniprot.org/uniprotkb/P34998/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Subcellular UniProt: #Cell membrane #Endosome #Membrane

Alternative name from UniProt:

Recommended name: Corticotropin-releasing factor receptor 1

Gene name from HGNC: CRHR1 (CRF-R, CRF1, CRHR)

HPA class: FDA approved drug targets G-protein coupled receptors Transporters

AlphaFold DB: P34998

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P34998

HPA link: https://www.proteinatlas.org/ENSG00000120088-CRHR1

Tissue specificity RNA from HPA: Group enriched (brain, pituitary gland)

Tissue expression from HPA: Cytoplasmic expression mainly in anterior pituitary gland and brain.

Single cell type specificity Group enriched (Late spermatids, Early spermatids)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000120088-CRHR1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000120088-CRHR1/pathology/endometrial+cancer

Expression figure legend: Immunohistochemistry for CRH (A), CRHR1 (B), and CRHR2 (C) in endometrial carcinoma specimens.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215916/figure/F1/

Survival figure legend: Disease-free (A, C, and E) and overall (B, D, and F) survival

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215916/figure/F2/

OMIM: 122561

OMIM link2: https://www.omim.org/entry/122561

HGNC ID: HGNC:2357

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2357