Biomarker: IMP3

Histology type: endometrial serous carcinomas

Country: Spain

Region: Lleida

Followed up time :

Subgroup 1 name : EEC

Subgroup 1 number: 57

Subgroup 2 name: SC

Subgroup 2 number: 31

Conclusion: We propose an internally and externally validated 9-protein biomarker signature to predict the histologic type of EC (EEC or SC) by IHC. The results also suggest that mixed EEC-SC is molecularly ambiguous.

Sample type : tissue

Sample method: immunohistochemistry (IHC)

Expression pattern : IMP3 ≥ 2

Expression elevation: IHC staining was graded semiquantitatively by considering the percentage and intensity of the staining. A histologic score (Hs) was obtained from each sample, and values ranged from 0 (no immunoreaction) to 300 (maximum immunoreactivity). The score was obtained by applying the following formula, Hs = 1 × (% light staining) + 2 × (% moderate staining) + 3 × (% strong staining). Scoring was independently performed by 2 of the authors (M. S. and O. M.). Interobserver agreement between these 2 authors was assessed by Cohen κ concordance measure, considering all the intervals in Hs range (0-300) at each 10 units, and with Pearson linear correlation.

Funtion Uniprot: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.

UniProt ID: Q9NV31

UniProt Link: https://www.uniprot.org/uniprotkb/Q9NV31/entry

Biological function from UniProt: #Ribosome biogenesis #rRNA processing

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: U3 small nucleolar ribonucleoprotein protein IMP3

Gene name from HGNC: IMP3 (BRMS2, C15orf12, FLJ10968, MRPS4)

HPA class: Plasma proteins Ribosomal proteins

AlphaFold DB: Q9NV31

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NV31

HPA link: https://www.proteinatlas.org/ENSG00000177971-IMP3

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli (Single cell variability)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000177971-IMP3/pathology/endometrial+cancer

OMIM: 612980

OMIM link2: https://www.omim.org/entry/612980

HGNC ID: HGNC:14497

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14497