Biomarker: IMP2

Histology type: endometrial serous carcinomas

Country: Spain

Region: Lleida

Followed up time :

Subgroup 1 name : EEC

Subgroup 1 number: 57

Subgroup 2 name: SC

Subgroup 2 number: 31

Conclusion: We propose an internally and externally validated 9-protein biomarker signature to predict the histologic type of EC (EEC or SC) by IHC. The results also suggest that mixed EEC-SC is molecularly ambiguous.

Sample type : tissue

Sample method: immunohistochemistry (IHC)

Expression pattern : IMP2 ≥ 115

Expression elevation: IHC staining was graded semiquantitatively by considering the percentage and intensity of the staining. A histologic score (Hs) was obtained from each sample, and values ranged from 0 (no immunoreaction) to 300 (maximum immunoreactivity). The score was obtained by applying the following formula, Hs = 1 × (% light staining) + 2 × (% moderate staining) + 3 × (% strong staining). Scoring was independently performed by 2 of the authors (M. S. and O. M.). Interobserver agreement between these 2 authors was assessed by Cohen κ concordance measure, considering all the intervals in Hs range (0-300) at each 10 units, and with Pearson linear correlation.

Funtion Uniprot: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

UniProt ID: Q96T52

UniProt Link: https://www.uniprot.org/uniprotkb/Q96T52/entry#function

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in all tissues tested except adult liver and lung.

Subcellular UniProt: #Membrane #Mitochondrion #Mitochondrion inner membrane

Alternative name from UniProt:

Recommended name: Mitochondrial inner membrane protease subunit 2

Gene name from HGNC: IMMP2L (IMMP2L-IT1, IMP2)

HPA class: Disease related genes Enzymes Potential drug targets

AlphaFold DB: Q96T52

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q96T52

HPA link: https://www.proteinatlas.org/ENSG00000184903-IMMP2L

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous cytoplasmic expression.

Single cell type specificity Group enriched (Microglial cells, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Astrocytes, Oligodendrocytes, Distal tubular cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Mitochondria

Cancer prognostic summary HPA Prognostic marker in head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000184903-IMMP2L/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000184903-IMMP2L/pathology/endometrial+cancer

Phenotype ID: 137580

Disease: Gilles de la Tourette syndrome (GTS)

Note1: The disease may be caused by variants affecting the gene represented in this entry

OMIM: 605977

OMIM link1: https://www.omim.org/entry/137580

OMIM link2: https://www.omim.org/entry/605977

HGNC ID: HGNC:14598

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14598