Biomarker: PR

Histology type: endometrial carcinoma

Stage: risk

Study type: Retrospective multicenter study

Followed up time :

Subgroup 1 name : negative

Subgroup 1 number: 151

Subgroup 2 name: positive

Subgroup 2 number: 612

Conclusion: p53/L1CAM/ER/PR expression could serve as indicator for surgical staging and refine selective adjuvant treatment by incorporation into the ESMO-ESGO-ESTRO risk classification.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : p53/L1CAM/ER/PR expression,for ER/PR-

Expression elevation: For ER and PR, the number of stained tumor nuclei was scored. Cases were also dichotomized, using 10% as a cut-off value.ER and/or PR expression was considered abnormal when <10% nuclear staining was present (ER/PR-).

Statictics: Mean (SD)

Cohort age: 65.2 ± 10.2

Funtion Uniprot: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.3 PublicationsCurated Isoform A Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.3 Publications2 Publications Isoform B Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.1 Publication Isoform 4 Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

UniProt ID: P06401

UniProt Link: https://www.uniprot.org/uniprotkb/P06401/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli

Subcellular UniProt: #Cytoplasm #Membrane #Mitochondrion #Mitochondrion outer membrane #Nucleus

Alternative name from UniProt:

Recommended name: Progesterone receptor

Gene name from HGNC: PGR (NR3C3, PR)

HPA class: Cancer-related genes FDA approved drug targets Nuclear receptors Transcription factors Transporters

AlphaFold DB: P06401

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P06401

HPA link: https://www.proteinatlas.org/ENSG00000082175-PGR

Tissue specificity RNA from HPA: Group enriched (cervix, endometrium, fallopian tube, smooth muscle)

Tissue expression from HPA: Selective nuclear expression in female reproductive system and smooth muscle.

Single cell type specificity Cell type enhanced (Endometrial stromal cells, Endometrial ciliated cells, Glandular and luminal cells, Early spermatids, Late spermatids)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000082175-PGR/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000082175-PGR/pathology/endometrial+cancer

Survival figure legend: RFS for ESMO-ESGO-ESTRO risk groups and p53-expression. B. RFS for ESMO-ESGO-ESTRO risk groups and L1CAM-expression C. RFS for ESMO-ESGO-ESTRO risk groups and ER/PR-expression.

Survival curve link: https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/9bdaf4c2-b783-4a6d-8cae-7682434613a8/gr3.jpg

OMIM: 607311

OMIM link2: https://www.omim.org/entry/607311

HGNC ID: HGNC:8910

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8910