Basic information
Biomarker: cyclin B
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: Finland
Region: Oulu
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 211 | endometrial endometrioid adenocarcinoma | 211 |
Sample information
Conclusion: In multivariate analysis, the results were indicative that cyclin B may hold independent prognostic significance, but further studies are required to assess this.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : Overexpression
Expression elevation: Cyclin B positivity was evaluated as a percentage of positive cells by evaluating the whole tumor section.
Disease information
Related information
Funtion Uniprot: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
UniProt ID: P14635
UniProt Link: https://www.uniprot.org/uniprotkb/P14635/entry
Biological function from UniProt: #Cell cycle #Cell division #Mitosis
Molecular function from UniProt:
Tissue specificity from UniProt: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
Subcellular UniProt: #Cytoplasm #Cytoskeleton #Nucleus
Recommended name: G2/mitotic-specific cyclin-B1
Gene name from HGNC: CCNB1 (CCNB)
HPA class: Cancer-related genes Plasma proteins Transporters
AlphaFold DB: P14635
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P14635
HPA link: https://www.proteinatlas.org/ENSG00000134057-CCNB1
Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, lymphoid tissue)
Tissue expression from HPA: Cytoplasmic expression in proliferating cells.
Single cell type specificity Cell type enriched (Extravillous trophoblasts)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Cytosol (Single cell variability, CCD Protein, CCD Transcript)
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), liver cancer (unfavorable) and lung cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000134057-CCNB1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000134057-CCNB1/pathology/endometrial+cancer
OMIM: 123836
OMIM link2: https://www.omim.org/entry/123836
HGNC ID: HGNC:1579
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1579
