Biomarker: SATB1

Histology type: endometrial carcinoma

Country: China

Region: Harbin

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 172

Subgroup 2 name: normal endometrial tissues

Subgroup 2 number: 25

Conclusion: Results showed that SATB1 may be involved in tumor development and progression in endometrial cancer, may serve as a promising biomarker for predicting the prognosis of endometrial cancer patients, and thus may act as a novel target for treating endometrial carcinoma.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : Overexpression(>1The final score was calculated by multiplying the proportion score with the staining intensity score, which was 0, 1, 2, 3, 4, 6, 9. Scores less than or equal to 1 were categorized as SATB1 negative, and scores greater than 1 were categorized as SATB1 positive.)

Expression elevation: The percentage of positive tumor cells was scored as follows: 1, 0% to 9% positive cells; 2, 10% to 50% positive cells; and 3, more than 50% positive cells. The staining intensity was scored as follows: 0, negative staining; 1, weak staining; 2, moderate staining; and 3, intense staining. The final score was calculated by multiplying the proportion score with the staining intensity score, which was 0, 1, 2, 3, 4, 6, 9. Scores less than or equal to 1 were categorized as SATB1 negative, and scores greater than 1 were categorized as SATB1 positive

Funtion Uniprot: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity).

UniProt ID: Q01826

UniProt Link: https://www.uniprot.org/uniprotkb/Q01826/entry

Biological function from UniProt: #Host-virus interaction #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed predominantly in thymus.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: DNA-binding protein SATB1

Gene name from HGNC: SATB1

HPA class: Plasma proteins Transcription factors

AlphaFold DB: Q01826

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q01826

HPA link: https://www.proteinatlas.org/search/SATB1

Tissue specificity RNA from HPA: Tissue enriched (lymphoid tissue)

Tissue expression from HPA: Nuclear expression in several tissues, mainly in cells of the CNS and immune system.

Single cell type specificity Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity: Immune cell enhanced (naive CD4 T-cell)

Subcellular summary HPA Located in Nucleoplasm, Nuclear bodies

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable) and pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000182568-SATB1/pathology

Phenotype ID: 619229

Disease: Kohlschutter-Tonz syndrome-like (KTZSL)

Note1: The disease is caused by variants affecting the gene represented in this entry

Note2: A number sign (#) is used with this entry because of evidence that developmental delay with dysmorphic facies and dental anomalies (DEFDA) is caused by heterozygous mutation in the SATB1 gene (602075) on chromosome 3p24. Heterozygous mutation in the SATB1 gene can also cause a similar but more severe disorder (KTZSL; 619229).

OMIM: 602075;

OMIM link1: https://www.omim.org/entry/619229

OMIM link2: https://www.omim.org/entry/602075

Phenotype: Developmental delay with dysmorphic facies and dental anomalies

HGNC ID: HGNC:10541

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10541