Biomarker: HAND2

Histology type: endometrioid endometrial carcinoma

Country: USA

Region: Texas

Followed up time :

Subgroup 1 name : positive in EC

Subgroup 1 number: 0

Subgroup 2 name: nagtive in EC

Subgroup 2 number: 22

Conclusion: The absence of Hand2 expression may be a useful biomarker for atypical hyperplasia and endometrioid endometrial carcinoma .

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : Loss expression

Expression elevation: Cells exhibiting nuclear staining of Hand2 were considered positive,and expression was graded on a semiquantitative 3-tiered scale as weak, moderate, or strong.

Funtion Uniprot: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).

UniProt ID: P61296

UniProt Link: https://www.uniprot.org/uniprotkb/P61296/entry

Biological function from UniProt: #Angiogenesis #Differentiation #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Heart.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Heart- and neural crest derivatives-expressed protein 2

Gene name from HGNC: HAND2 (bHLHa26, dHand, Hed, Thing2)

HPA class: Transcription factors

AlphaFold DB: P61296

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P61296

Developmental stage: Expressed in the fetal heart.

HPA link: https://www.proteinatlas.org/ENSG00000164107-HAND2

Tissue specificity RNA from HPA: Tissue enhanced (intestine)

Tissue expression from HPA: Nuclear expression in several tissues.

Single cell type specificity Group enriched (Endometrial stromal cells, Cardiomyocytes)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Vesicles

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000164107-HAND2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000164107-HAND2/pathology/endometrial+cancer

OMIM: 602407

OMIM link2: https://www.omim.org/entry/602407

HGNC ID: HGNC:4808

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4808