Biomarker: RAB8A

Histology type: endometrial carcinoma

Country: China

Region: Beijing

Study type: Comparative Study

Followed up time :

Conclusion: RAB8A might be a new biomarker for endometrial cancer. Using LC-MS/MS to perform a comparative proteomic analysis about DCs and tumor lysate-pulsed DCs may help us to find new biomarker of cancer.

Expression pattern : expression

Funtion Uniprot: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:21844891, PubMed:30398148). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069)

UniProt ID: P61006

UniProt Link: https://www.uniprot.org/uniprotkb/P61006/entry

Biological function from UniProt: #Autophagy #Cilium biogenesis/degradation #Protein transport #Transport

Molecular function from UniProt:

Subcellular UniProt: #Cell membrane #Cell projection #Cilium #Cytoplasm #Cytoplasmic vesicle

Alternative name from UniProt:

Catalytic activity: GTP + H2O = GDP + H+ + phosphate;This reaction proceeds in the forward direction.;

Activity regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (Probable). Activated in response to insulin (By similarity).

Recommended name: Ras-related protein Rab-8A

Gene name from HGNC: RAB8A (MEL, RAB8)

AlphaFold DB: P61006

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P61006

HPA link: https://www.proteinatlas.org/ENSG00000167461-RAB8A

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and thyroid cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000167461-RAB8A/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000167461-RAB8A/pathology/endometrial+cancer

OMIM: 165040

OMIM link2: https://www.omim.org/entry/165040

HGNC ID: HGNC:7007

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7007