Biomarker: CA125

Histology type: endometrial carcinoma

Stage: stage I

Country: China

Region: Shengjing

Study type: prospective study

Followed up time :

Conclusion: Preoperative serum CA125: a useful marker for surgical management of endometrial cancer

Sample type : serum

Sample method: ELISA

Expression pattern : cutoff=30U/ml(evaluate adnexal involement)25 U/mL( lymph node metastasis)

Statictics: cutoff<50;cutoff>50

Cohort age: 742;354

Funtion Uniprot: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

UniProt ID: Q8WXI7

UniProt Link: https://www.uniprot.org/uniprotkb/Q8WXI7/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.

Subcellular UniProt: #Cell membrane #Membrane #Secreted

Alternative name from UniProt:

Miscellaneous: Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.

Gene name from HGNC: MUC16 (CA125, FLJ14303)

HPA class: Plasma proteins

AlphaFold DB: SMR Q8WXI7

AlphaFold Link: https://swissmodel.expasy.org/repository/uniprot/Q8WXI7?csm=7D5E9A14F70EB90A

Induction: Up-regulated in ovarian cancer cells.

HPA link: https://www.proteinatlas.org/ENSG00000181143-MUC16

Tissue specificity RNA from HPA: Group enriched (adipose tissue, cervix, fallopian tube, salivary gland)

Tissue expression from HPA: Cytoplasmic and membranous expression in glandular cells of cervix, endometrium, fallopian tube, salivary gland and respiratory epithelium.

Single cell type specificity Cell type enhanced (Respiratory ciliated cells, Glandular and luminal cells, Ionocytes, Club cells, Endometrial ciliated cells, Basal respiratory cells)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000181143-MUC16/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000181143-MUC16/pathology/endometrial+cancer

Expression figure legend: The receiver operating characteristic (ROC) curve of preoperative serum CA125 for predicting lymph node metastasis in patients with clinical stage I.$ The receiver operating characteristic (ROC) curve of preoperative serum CA125 for predicting adnexal involvement in patients with clinical stage I.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438478/figure/Fig2/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438478/figure/Fig3/

Survival figure legend: Survival curves in relation to different preoperative serum CA125 group.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438478/figure/Fig4/

OMIM: 606154

OMIM link2: https://www.omim.org/entry/606154

HGNC ID: HGNC:15582

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15582