Biomarker: Musashi-1 protein

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Shanghai

Followed up time :

Subgroup 1 name : EAC

Subgroup 1 number: 35

Subgroup 2 name: normal endometrium (NE)

Subgroup 2 number: 15

Conclusion: Our results suggest high level of Musashi-1 protein expression is associated with poor survival in EAC patients;which may be an independent prognostic factor for EAC.

Sample type : tissue

Sample method: RT-PCR/immunohistochemistry

Expression pattern : high expression

Expression elevation: The intensity of the positive result was scored as follows: 0, negative; 1, weak; 2, moderate; 3, high. The extent of positivity was scored according to the percentage of cells that stained positive: no staining or < 10% is 0; 11 to 30% is 1; 31 to 50% is 2; > 51% is 3. The final score was determined by multiplying the intensity of positivity and the extent of positivity scores. Scored 0 were taken as negative, scored less than 4 as low expression, scored 4 to 6 as moderate expression, and scored 6 to 9 as high expression.

Subgroup 1 age: 54±9.08;30-80

Subgroup 2 age: 50±5.28;45-60

Funtion Uniprot: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

UniProt ID: O43347

UniProt Link: https://www.uniprot.org/uniprotkb/O43347/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: RNA-binding protein Musashi homolog 1

Gene name from HGNC: MSI1

AlphaFold DB: O43347

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O43347

HPA link: https://www.proteinatlas.org/ENSG00000135097-MSI1

Tissue specificity RNA from HPA: Tissue enriched (retina)

Tissue expression from HPA: Cytoplasmic and nuclear expression in several tissues, including CNS and retina.

Single cell type specificity Cell type enhanced (Rod photoreceptor cells, Muller glia cells, Late spermatids, Early spermatids, Cone photoreceptor cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Cytosol

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000135097-MSI1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000135097-MSI1/pathology/endometrial+cancer

OMIM: 603328

OMIM link2: https://www.uniprot.org/uniprotkb/O43347/external-links

HGNC ID: HGNC:7330

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7330