Biomarker: IFITM1

Histology type: endometrial stromal tumor

Country: China

Region: Xinjiang

Study type: retrospective study

Followed up time :

Subgroup 1 name : endometrial stromal tumor

Subgroup 1 number: 30

Subgroup 2 name: cellular leiomyoma

Subgroup 2 number: 33

Conclusion: IFITM1, CD10, SMA, and h-caldesmon are a good combination for the differential diagnosis of EST and CL.

Sample type : tissue

Sample method: immunohistochemical staining

Expression pattern : expression

Expression elevation: The extent of staining was evaluated as 0%, 0–25%, 26–50%, 51–75%, and 76–100%, and the intensity of staining as absent (0), weak (1+), moderate (2+), and strong (3+). When a different staining evaluation was used, the higher intensity score was used as the final score. The staining score was obtained by multiplying percentage with intensity and this score was used for our statistics analysis.

Statictics: Median;Range

Subgroup 1 age: 49.5 ;(27–73)

Subgroup 2 age: 41 ;(26–60)

Funtion Uniprot: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436).

UniProt ID: P13164

UniProt Link: https://www.uniprot.org/uniprotkb/P13164/entry

Biological function from UniProt: Antiviral defense, Immunity, Innate immunity, Osteogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.

Subcellular UniProt: #Cell membrane #Lysosome #Membrane

Alternative name from UniProt:

Recommended name: Methylcytosine dioxygenase TET1

Gene name from HGNC: IFITM1 (9-27, CD225, DSPA2a, IFI17)

CD antigen name: CD225

HPA class: CD markers Plasma proteins Transporters

AlphaFold DB: P13164

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P13164

Induction: By IFN-alpha and IFNG/IFN-gamma.

HPA link: https://www.proteinatlas.org/ENSG00000185885-IFITM1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Distinct membranous expression in epididymis, also expressed in endothelial cells and in lymphoid tissue.

Single cell type specificity Cell type enhanced (Basal squamous epithelial cells, T-cells, Endothelial cells, Leydig cells, Sertoli cells)

Immune cell specificity: Group enriched (NK-cell, memory CD4 T-cell, memory CD8 T-cell, naive CD8 T-cell, naive CD4 T-cell, gdT-cell, neutrophil, MAIT T-cell, T-reg, eosinophil)

Subcellular summary HPA Located in Golgi apparatus, Plasma membrane, Cytosol (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000185885-IFITM1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000185885-IFITM1/pathology/endometrial+cancer

OMIM: 604456

OMIM link2: https://www.omim.org/entry/604456

HGNC ID: HGNC:5412

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5412