Biomarker: CXCR7

Histology type: endometrial carcinoma

Followed up time :

Conclusion: CXCR7 expected to become two target genes for the treatment of endometrial carcinoma.The expression levels of CXCR7 could be inhibited by RNA interference, reducing the cell proliferation, invasion in Ishikawa and HEC-1-A cells.

Sample method: RT-PCR/Western blotting

Expression pattern : expression

Funtion description: The expression levels of CXCR4 and CXCR7 could be inhibited by RNA interference, reducing the cell proliferation, invasion in Ishikawa and HEC-1-A cells. In this study, we also observed that treated with CXCR4 and CXCR7 small interfering RNA (siRNA) arrested cells in S phase. CXCL12/CXCR4 and CXCL12/CXCR7 receptor ligand systems affect the invasion of endometrial carcinoma cell line into Ishikawa and HEC-1-A. CXCR4 and CXCR7 were silenced by RNAi, which can inhibit the invasion of Ishikawa and HEC-1-A cell lines.

Funtion Uniprot: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835).13 Publications (Microbial infection) Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

UniProt ID: P25106

UniProt Link: https://www.uniprot.org/uniprotkb/P25106/entry

Biological function from UniProt: #Cell adhesion #Host-virus interaction

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level).

Subcellular UniProt: #Cell membrane #Endosome #Membrane

Alternative name from UniProt:

Caution: Was originally thought to be the receptor for VIP.

Recommended name: Atypical chemokine receptor 3

Gene name from HGNC: ACKR3 (CMKOR1, CXCR7, GPR159, RDC1)

HPA class: Cancer-related genes G-protein coupled receptors

AlphaFold DB: P25106

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P25106

Induction: Up-regulated during cell differentiation in glioma cells.

HPA link: https://www.proteinatlas.org/ENSG00000144476-ACKR3

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression at variable levels in several different cell types, including trophoblasts and immune cells.

Single cell type specificity Cell type enhanced (Fibroblasts, Endothelial cells, Basal respiratory cells, Smooth muscle cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Vesicles, Plasma membrane

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), stomach cancer (unfavorable), urothelial cancer (unfavorable) and cervical cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000144476-ACKR3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000144476-ACKR3/pathology/endometrial+cancer

Phenotype ID: 619215

Disease: Oculomotor-abducens synkinesis (OCABSN)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 610376

OMIM link1: https://www.omim.org/entry/619215

OMIM link2: https://www.omim.org/entry/610376

HGNC ID: HGNC:23692

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23692