Biomarker: NRP-1

Histology type: endometrial carcinoma

Stage: early stage

Country: USA

Region: the OUHSC Stephenson Cancer Center (SCC) Biospecimen Acquisition Core and Bank

Study type: Comparative Study

Followed up time :

Subgroup 1 name : EC tissues

Subgroup 1 number: 94

Subgroup 2 name: EC serum

Subgroup 2 number: 94

Conclusion: In conclusion, findings from this study suggest that aberrant NRP-1 expression may serve as an early biomarker for metastatic endometrial tumors, and potentially influence novel therapies to complement existing interventions.

Sample type : serum

Sample method: Western blot

Expression pattern : aberrant NRP-1 expression

Statictics: Mean (SD);Range

Cohort age: 60.02;34–88

Funtion Uniprot: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:9288753, PubMed:9529250, PubMed:10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:9288753, PubMed:9529250, PubMed:10688880, PubMed:19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).By Similarity5 Publications (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.2 Publications Isoform 2 Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity

UniProt ID: O14786

UniProt Link: https://www.uniprot.org/uniprotkb/O14786/entry

Biological function from UniProt: #Angiogenesis #Differentiation #Host-virus interaction #Neurogenesis

Molecular function from UniProt:

Tissue specificity from UniProt: Isoform 1 The expression of isoforms 1 and 2 does not seem to overlap. Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293).Isoform 2 The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules.

Subcellular UniProt: #Cell membrane #Cytoplasm #Membrane #Mitochondrion #Secreted

Alternative name from UniProt:

Recommended name: Neuropilin-1

Gene name from HGNC: NRP1 (CD304, NRP, VEGF165R)

CD antigen name: CD304

HPA class: Cancer-related genes CD markers Plasma proteins Transporters

AlphaFold DB: O14786

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O14786

HPA link: https://www.proteinatlas.org/ENSG00000099250-NRP1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Extracellular staining in most tissues.

Single cell type specificity Cell type enhanced (Adipocytes, Sertoli cells, Hepatic stellate cells, Endothelial cells)

Immune cell specificity: Immune cell enriched (plasmacytoid DC)

Cancer prognostic summary HPA Prognostic marker in stomach cancer (unfavorable), cervical cancer (unfavorable), renal cancer (unfavorable) and glioma (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000099250-NRP1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000099250-NRP1/pathology/endometrial+cancer

OMIM: 602069

OMIM link2: https://www.omim.org/entry/602069

HGNC ID: HGNC:8004

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8004