Basic information
Biomarker: CRIP-1
Histology type: endometrial carcinoma
Cohort characteristics
Country: Greece
Region: Thessaloniki
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 46 | EC | 46 |
Sample information
Conclusion: In conclusion, we found that the two proteins follow the same expression pattern and that their co-expression is strongly correlated with poor prognosis and short survival.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : co-expression of galectin-3 and CRIP-1
Expression elevation: The average labeling index of GAL-3 and CRIP-1 was assessed according to the proportion of positive cells, after scanning the entire section of the specimen. Sections were graded as negative (0) for <10 % of stained cells, low (1) for 10–30 % of stained cells, moderate (2) for 30–70 % of stained cells and high (3) for >70 % of stained cells. Staining intensity was equal between different samples and areas of the tissue sections, and therefore, it was not included in the scoring
Disease information
Statictics: Mean (SD)
Cohort age: 60.02 ± 10.61
Related information
Funtion Uniprot: Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
UniProt ID: P50238
UniProt Link: https://www.uniprot.org/uniprotkb/P50238/entry
Molecular function from UniProt:
Alternative name from UniProt:
Recommended name: Cysteine-rich protein 1
Gene name from HGNC: CRIP1 (CRIP)
HPA class: Plasma proteins
AlphaFold DB: P50238
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P50238
HPA link: https://www.proteinatlas.org/ENSG00000213145-CRIP1
Tissue specificity RNA from HPA: Low tissue specificity
Tissue expression from HPA: Cytoplasmic expression in most cell types, high levels in squamous epithelia, fibroblasts and blood vessels.
Single cell type specificity Cell type enhanced (Proximal tubular cells)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Located in Nuclear speckles, Plasma membrane, Centrosome, Cytosol
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000213145-CRIP1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000213145-CRIP1/pathology/endometrial+cancer
OMIM: 123875
OMIM link2: https://www.omim.org/entry/123875
HGNC ID: HGNC:2360
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2360
