Biomarker: Nup88

Histology type: benign tumor

Stage: early stage

Country: China

Region: Hebei

Study type: retrospective study

Followed up time :

Subgroup 1 name : negative

Subgroup 1 number: 14

Subgroup 2 name: positive

Subgroup 2 number: 36

Conclusion: Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions. Nup88 might be a useful biomarker for pre-malignant lesions and early-stage endometrial cancer.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: The intensity of the staining was graded as 0 for negative, 1 for weak, 2 for moderate, or 3 for strong. The percentage of stained cells was classified as 0 for <5% staining, 1 for 6–25%, 2 for 26–50%, and 3 for >50%. The final score was defined as the sum of the staining intensity and the percentage in each case, i.e. 0–6 points. In the statistical analysis,0–2 points were considered as negative and ≥3 points as positive.

Statictics: cutoff<55;cutoff>55

Cohort age: 21;29

Subgroup 1 age: 8;6

Subgroup 2 age: 13;23

Funtion Uniprot: Component of nuclear pore complex.

UniProt ID: Q99567

UniProt Link: https://www.uniprot.org/uniprotkb/Q99567/entry

Biological function from UniProt: #mRNA transport #Protein transport #Translocation #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous.

Subcellular UniProt: #Nuclear pore complex #Nucleus

Alternative name from UniProt:

Recommended name: Nuclear pore complex protein Nup88

Gene name from HGNC: NUP88 (MGC8530)

HPA class: Disease related genes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters

AlphaFold DB: Q99567

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q99567

HPA link: https://www.proteinatlas.org/ENSG00000108559-NUP88

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear expression in most tissues.

Single cell type specificity Cell type enhanced (Spermatocytes, Early spermatids)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000108559-NUP88/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000108559-NUP88/pathology/endometrial+cancer

Phenotype ID: 618393

Disease: Fetal akinesia deformation sequence 4 (FADS4)

Note1: The disease is caused by variants affecting the gene represented in this entry. Disease mechanism likely includes impaired formation of the neuromuscular junction. NUP88 silencing in vitro results in reduced levels of rapsyn, a key player in clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. Decreased rapsyn levels have also been observed in a patient muscle biopsy

OMIM link1: https://www.omim.org/entry/618393

HGNC ID: HGNC:8067

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8067