Biomarker: Estrogen receptor-alpha

Histology type: endometrioid endometrial carcinoma

Stage: higher grade and advanced stage

Country: United States

Followed up time :

Subgroup 1 name : negative

Subgroup 1 number: 60

Subgroup 2 name: positive

Subgroup 2 number: 263

Conclusion: Estrogen receptor-alpha as a predictive biomarker in endometrioid endometrial cancer.Patients with ERα negative endometrioid endometrial cancer are more often diagnosed with higher grade and advanced stage disease.

Sample type : tissue

Sample method: immunohistochemistry,digital image analysis,amplicon-based sequencing

Expression pattern : negative

Expression elevation: ERα expression was recorded as the percentage of stained cells, and classified by dichotomizing IHC expression regardless of intensity as present (≥ 1% staining cells) or absent (<1%) per ASCO/College of American Pathologists Guidelines [12]. To confirm accurate interpretation by digital analysis software cores with <5% ERα expression were reviewed by a pathologist (AAS) and visually scored as ERα- positive or - negative.

Statictics: Mean

Cohort age: 59.7

Subgroup 1 age: 61.4

Funtion Uniprot: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

UniProt ID: P11474

UniProt Link: https://www.uniprot.org/uniprotkb/P11474/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: Steroid hormone receptor ERR1

Gene name from HGNC: ESRRA (ERR1, ERRa, ERRalpha, ESRL1, NR3B1)

HPA class: Nuclear receptors Transcription factors

AlphaFold DB: P11474

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P11474

Induction: Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.

HPA link: https://www.proteinatlas.org/ENSG00000173153-ESRRA

Tissue specificity RNA from HPA: Tissue enhanced (skeletal muscle)

Tissue expression from HPA: General cytoplasmic expression.

Single cell type specificity Cell type enhanced (Hepatocytes, Proximal enterocytes, Distal enterocytes)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm, Nucleoli fibrillar center, Microtubules, Cytokinetic bridge (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000173153-ESRRA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000173153-ESRRA/pathology/endometrial+cancer

Expression figure legend: Representative examples of ERα staining

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878441/figure/F1/

OMIM: 601998

OMIM link2: https://www.omim.org/entry/601998

HGNC ID: HGNC:3471

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3471