Biomarker: E2F1

Histology type: endometrial carcinoma

Country: Sweden

Region: Stockholm

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 42

Subgroup 2 name: normal endometrium (NE)

Subgroup 2 number: 84

Conclusion: We conclude that high expression of S18-2 and free E2F1, and low pan-keratin, beta-catenin, and E-cadherin signals might be a good set of prognostic markers for EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : combination of high S18-2 and free E2F1 expression

Funtion Uniprot: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17704056, PubMed:17050006, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599).

UniProt ID: Q01094

UniProt Link: https://www.uniprot.org/uniprotkb/Q01094/entry

Biological function from UniProt: #Apoptosis #Cell cycle #Host-virus interaction #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Catalytic activity: BIRC2/c-IAP1 stimulates its transcriptional activity.

Recommended name: Transcription factor E2F1

Gene name from HGNC: E2F1 (RBBP3, RBP3)

HPA class: Cancer-related genes Plasma proteins Transcription factors

AlphaFold DB: Q01094

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q01094

HPA link: https://www.proteinatlas.org/ENSG00000101412-E2F1

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow)

Tissue expression from HPA: Nuclear expression in most tissues.

Single cell type specificity Cell type enhanced (Spermatogonia, Erythroid cells, Granulosa cells)

Immune cell specificity: Immune cell enhanced (non-classical monocyte)

Subcellular summary HPA Located in Nucleoplasm, Centrosome (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in cervical cancer (favorable), liver cancer (unfavorable), endometrial cancer (unfavorable), renal cancer (unfavorable), thyroid cancer (favorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000101412-E2F1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000101412-E2F1/pathology/endometrial+cancer

Expression figure legend: S18-2 protein expression in cancerous and normal cells

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008351/figure/F1/

OMIM: 189971

OMIM link2: https://www.omim.org/entry/189971

HGNC ID: HGNC:3113

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3113