Biomarker: SLUG

Histology type: endometrial carcinoma

Stage: high grade

Country: Japan

Region: Tokyo

Followed up time :

Subgroup 1 name : high expression

Subgroup 1 number: 13

Subgroup 2 name: Low expression

Subgroup 2 number: 39

Conclusion: A high expression level of SLUG can be an indicator of recurrence and a therapeutic target for long-term remission in high-grade endometrial carcinomas.A high expression level of SLUG can be an indicator of recurrence and a therapeutic target for long-term remission in high-grade endometrial carcinomas.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : high expression

Expression elevation: The expression extent of SNAIL and SLUG was evaluated semiquantitatively as follows: 1+ for <25% positive tumour cells, 2+ for 25–50%, 3+ for 51–75% and 4+ for >75%. They were then categorized into low (1+ and 2+) and high (3+ and 4+) for statistical analysis, based on the study by Wang et al.Most of the stained sections demonstrated notable differences between the high and low groups, although some sections stained with SLUG antibody had discordant scores between 1+ and 2+ or between 3+ and 4+.

Statictics: Mean ;Range

Cohort age: 62.5;37–87

Funtion Uniprot: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis

UniProt ID: O43623

UniProt Link: https://www.uniprot.org/uniprotkb/O43623/entry#function

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Recommended name: Zinc finger protein SNAI2

Gene name from HGNC: SNAI2 (SLUG, SLUGH, SLUGH1, SNAIL2)

HPA class: Disease related genes Human disease related genes Transcription factors

AlphaFold DB: O43623

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O43623

HPA link: https://www.proteinatlas.org/ENSG00000019549-SNAI2

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: General nuclear expression.

Single cell type specificity Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Endometrial stromal cells, Basal prostatic cells, Basal respiratory cells, Melanocytes)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), urothelial cancer (unfavorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000019549-SNAI2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000019549-SNAI2/pathology/endometrial+cancer

Phenotype ID: 608890;172800;

Disease: Waardenburg syndrome 2D (WS2D);Piebald trait (PBT);

Note1: The disease is caused by variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 172800

OMIM link1: https://www.omim.org/entry/608890;https://www.omim.org/entry/172800;

OMIM link2: https://www.omim.org/entry/172800

HGNC ID: HGNC:11094

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11094