Biomarker: CD103

Histology type: endometrioid endometrial carcinoma

Country: Dutch

Region: Groningen

Followed up time :

Conclusion: CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma.

Sample type : tissue

Sample method: immunohistochemistry/immunofluorescence

Expression pattern : high CD103+ cell infiltration

Expression elevation: Positively stained CD103+ cells were counted per core and the percentage of tumour/stromal surface was estimated.Patients were included if at least two cores contained≥20% tumour epithelium

Statictics: Mean

Cohort age: 56.9

Funtion Uniprot: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

UniProt ID: P38570

UniProt Link: https://www.uniprot.org/uniprotkb/P38570/entry#function

Biological function from UniProt: #Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Subcellular UniProt: #Membrane

Alternative name from UniProt:

Recommended name: Integrin alpha-E

Gene name from HGNC: Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

CD antigen name: CD103

HPA class: CD markers

AlphaFold DB: P38570

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P38570

Induction: Integrin alpha-E/beta-7 is induced by TGFB1

HPA link: https://www.proteinatlas.org/ENSG00000083457-ITGAE

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, intestine, lung)

Tissue expression from HPA: Distinct cytoplasmic expression in intraepithelial lymphocytes.

Single cell type specificity Low cell type specificity

Immune cell specificity: T-cells - T-cell receptor (mainly)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), endometrial cancer (favorable), urothelial cancer (favorable) and pancreatic cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000083457-ITGAE/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000083457-ITGAE/pathology/endometrial+cancer

OMIM: 604682

OMIM link2: https://www.omim.org/entry/604682

HGNC ID: HGNC:6147

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6147