Basic information
Biomarker: isoform B of progesterone receptor
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Beijing
Study type: retrospective cohort study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 53 | EC | 29 | EAH | 24 |
Sample information
Conclusion: For EC and EAH patients who received fertility-sparing therapy, baseline status of insulin resistance predicted poor response to progestin, while marked reduction of PRB following the initial 3–6 months' treatment predicted fast remission.
Sample type : tissue
Sample method: immunohistochemistry
Expression pattern : reduction of PRB (≥ 30%) at 3–6 months' treatment
Expression elevation: The product IHC score (0–3) for ER, PR, and PRB was calculated as the intensity of intranuclear staining (0, 1, 2, and 3) multiplied by the proportion of nuclear staining (0–1).
Disease information
Statictics: Mean (SD)
Cohort age: 31±5
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Changes in pathological markers at three time points during treatment.$Changes in pathological markers in patients with different treatment time to remission (< 6 months vs. ≥ 6 months).
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223344/figure/Fig2/$https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223344/figure/Fig3/
