Biomarker: HDACs 7

Histology type: endometrial stromal tumor

Stage: low grade

Country: Korea

Region: Angyang

Followed up time :

Conclusion: HDACs 1, 4, 6, 7, and 8, that showed an especially high frequency of strong immunoreactivity, may represent potential therapeutic targets for ESS.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : strong positive(181-300 was strongly positive (3+).percentage of the total width that was stained was then multiplied to yield the total score;)

Expression elevation: A semi-quantitative scoring system was used to determine the immunostaining intensity (categorized as 0, 1, 2, or 3). The percentage of the total width that was stained was then multiplied to yield the total score; 0-20 points was considered to be negative, 21-80 was weakly positive (1+), 81-180 was moderately positive (2+), and 181-300 was strongly positive (3+).

Statictics: Median;Range

Cohort age: 46;23-64

Funtion Uniprot: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758)

UniProt ID: Q8WUI4

UniProt Link: https://www.uniprot.org/uniprotkb/Q8WUI4/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Subcellular UniProt: #Cytoplasm #Nucleus

Alternative name from UniProt:

Miscellaneous: Its activity is inhibited by Trichostatin A (TSA), a known histone deacetylase inhibitor.

Catalytic activity: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]

Recommended name: Histone deacetylase 7

Gene name from HGNC: HDAC7 (DKFZP586J0917, HDAC7A)

HPA class: Enzymes FDA approved drug targets Plasma proteins

AlphaFold DB: Q8WUI4

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q8WUI4

HPA link: https://www.proteinatlas.org/ENSG00000061273-HDAC7

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Cell type enhanced (Hepatic stellate cells)

Immune cell specificity: Immune cell enriched (neutrophil)

Subcellular summary HPA Located in Cytosol

Cancer prognostic summary HPA Prognostic marker in urothelial cancer (favorable), melanoma (unfavorable) and renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000061273-HDAC7/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000061273-HDAC7/pathology/endometrial+cancer

Expression figure legend: Strong expression (3+) of histone deacetylase (HDACs) in endometrial stromal sarcoma. Images were provided by the Department of Pathology, Asan Medical Center (magnification ×200).

Expression figure link: https://ar.iiarjournals.org/content/anticanres/36/5/2527/F1.large.jpg

Survival figure legend: Disease-free survival based on the intensity of immunoreactivity (Semi-quantitative scoring system) for histone deacetylase (HDAC) 1, 4, 6, 7, and 8 in endometrial stromal sarcoma.

Survival curve link: https://ar.iiarjournals.org/content/anticanres/36/5/2527/F2.large.jpg

OMIM: 606542

OMIM link2: https://www.omim.org/entry/606542

HGNC ID: HGNC:14067

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14067