Biomarker: HDACs 1

Histology type: endometrial stromal tumor

Stage: low grade

Country: Korea

Region: Angyang

Followed up time :

Conclusion: HDACs 1, 4, 6, 7, and 8, that showed an especially high frequency of strong immunoreactivity, may represent potential therapeutic targets for ESS.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : strong positive(181-300 was strongly positive (3+).percentage of the total width that was stained was then multiplied to yield the total score;)

Expression elevation: A semi-quantitative scoring system was used to determine the immunostaining intensity (categorized as 0, 1, 2, or 3). The percentage of the total width that was stained was then multiplied to yield the total score; 0-20 points was considered to be negative, 21-80 was weakly positive (1+), 81-180 was moderately positive (2+), and 181-300 was strongly positive (3+).

Statictics: cutoff<50;cutoff>50

Cohort age: 34;7

Funtion Uniprot: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056). Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (PubMed:12837748, PubMed:16478997, PubMed:17996965, PubMed:19343227). Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997). Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374). Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374). Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227). Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776). Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810).

UniProt ID: Q13547

UniProt Link: https://www.uniprot.org/uniprotkb/Q13547/entry

Biological function from UniProt: #Biological rhythms #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Catalytic activity: H2O + N6-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone];This reaction proceeds in the forward direction.H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein] This reaction proceeds in the forward direction;H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein] This reaction proceeds in the forward direction.;

Recommended name: Histone deacetylase 1

Gene name from HGNC: HDAC1 (GON-10, HD1, KDAC1, RPD3L1)

HPA class: Enzymes FDA approved drug targets Plasma proteins

AlphaFold DB: Q13547

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q13547

HPA link: https://www.proteinatlas.org/ENSG00000116478-HDAC1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous nuclear expression.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in liver cancer (unfavorable) and renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000116478-HDAC1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000116478-HDAC1/pathology/endometrial+cancer

Expression figure legend: Strong expression (3+) of histone deacetylase (HDACs) in endometrial stromal sarcoma. Images were provided by the Department of Pathology, Asan Medical Center (magnification ×200).

Expression figure link: https://ar.iiarjournals.org/content/anticanres/36/5/2527/F1.large.jpg

Survival figure legend: Disease-free survival based on the intensity of immunoreactivity (Semi-quantitative scoring system) for histone deacetylase (HDAC) 1, 4, 6, 7, and 8 in endometrial stromal sarcoma.

Survival curve link: https://ar.iiarjournals.org/content/anticanres/36/5/2527/F2.large.jpg

OMIM: 601241

OMIM link2: https://www.omim.org/entry/601241

HGNC ID: HGNC:4852

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4852