Basic information
Biomarker: HE-4
Histology type: benign tumor
Cohort characteristics
Country: Turkey
Region: Istanbul
Study type: Comparative Study
Followed up time :
Subgroup 1 name : EC
Subgroup 1 number: 37
Subgroup 2 name: benign endometrial pathology
Subgroup 2 number: 70
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 107 | EC | 37 | benign endometrial pathology | 70 |
Sample information
Conclusion: Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.
Sample type : Serum
Sample method: ELISA
Expression pattern : cut off=458 pmol/L
Disease information
Statictics: Median;Range
Subgroup 1 age: 53;40-82
Subgroup 2 age: 64;45-85
Related information
Funtion Uniprot: Broad range protease inhibitor.
UniProt ID: Q14508
UniProt Link: https://www.uniprot.org/uniprotkb/Q14508/entry
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: WAP four-disulfide core domain protein 2
Gene name from HGNC: WFDC2 (dJ461P17.6, EDDM4, HE4, WAP5)
HPA class: Cancer-related genes
AlphaFold DB: Q14508
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14508
HPA link: https://www.proteinatlas.org/ENSG00000101443-WFDC2
Tissue specificity RNA from HPA: Tissue enhanced (cervix, salivary gland)
Tissue expression from HPA: Cytoplasmic expression in selected tissues.
Single cell type specificity Cell type enhanced (Club cells, Glandular and luminal cells, Basal respiratory cells, Urothelial cells, Endometrial ciliated cells, Respiratory ciliated cells, Collecting duct cells)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Secreted
Cancer prognostic summary HPA Prognostic marker in glioma (unfavorable) and renal cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000101443-WFDC2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000101443-WFDC2//pathology/endometrial+cancer
OMIM: 617548
OMIM link2: https://www.omim.org/entry/617548
HGNC ID: HGNC:15939
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939
