Biomarker: IL-33

Histology type: endometrial carcinoma

Country: China

Region: Sichuan

Study type: Comparative Study

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 160

Subgroup 2 name: healthy control

Subgroup 2 number: 160

Conclusion: This report is the first one mentioning the possible association between serum IL-31 and IL-33 and endometrial cancer. With their sensitivity and specificity, the interleukins may be useful biomarkers for endometrial cancer's prognosis.

Sample type : serum

Sample method: ELISA

Expression pattern : cut-off =98.42 pg/mL

Statictics: Mean (SD)

Subgroup 1 age: 54.13 ± 7.78

Subgroup 2 age: 54.03 ± 7.94

Funtion Uniprot: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).3 Publications In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or pro-inflammatory activation (PubMed:18787100).

UniProt ID: O95760

UniProt Link: https://www.uniprot.org/uniprotkb/O95760/entry

Biological function from UniProt: Transcription

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.

Subcellular UniProt: #Chromosome #Cytoplasm #Cytoplasmic vesicle #Nucleus #Secreted

Alternative name from UniProt:

Cleaved: Cleaved into 3 chains Interleukin-33 (95-270) Interleukin-33 (99-270) Interleukin-33 (109-270)

Recommended name: Interleukin-33

Gene name from HGNC: IL33 (C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV)

AlphaFold DB: O95760

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O95760

Induction: By infection with the parasite H.polygyrus.

HPA link: https://www.proteinatlas.org/ENSG00000137033-IL33

Tissue specificity RNA from HPA: Tissue enhanced (urinary bladder)

Tissue expression from HPA: High selective nuclear expression in endothelial cells, in a subset of immune cells in non-germinal center and in a subset of cells in epithelia.

Single cell type specificity Cell type enhanced (Hepatic stellate cells, Endothelial cells, Fibroblasts)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm, Vesicles (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in breast cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000137033-IL33/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000137033-IL33/pathology/endometrial+cancer

Expression figure legend: Comparison of the ROC curves among the serum levels of CEA, CA-125, CA19-9, IL-31, and IL-33.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906189/figure/fig2/

OMIM: 608678

OMIM link2: https://www.omim.org/entry/608678

HGNC ID: HGNC:16028

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16028