Basic information
Biomarker: IL-31
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Sichuan
Study type: Comparative Study
Followed up time :
Subgroup 1 name : EC
Subgroup 1 number: 160
Subgroup 2 name: healthy control
Subgroup 2 number: 160
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 320 | EC | 160 | healthy control | 160 |
Sample information
Conclusion: This report is the first one mentioning the possible association between serum IL-31 and IL-33 and endometrial cancer. With their sensitivity and specificity, the interleukins may be useful biomarkers for endometrial cancer's prognosis.
Sample type : serum
Sample method: ELISA
Expression pattern : cut-off =113.1 pg/mL
Disease information
Statictics: Mean (SD)
Subgroup 1 age: 54.13 ± 7.78
Subgroup 2 age: 54.03 ± 7.94
Related information
Funtion Uniprot: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity)
UniProt ID: Q6EBC2
UniProt Link: https://www.uniprot.org/uniprotkb/Q6EBC2/entry
Biological function from UniProt: Immunity
Molecular function from UniProt:
Tissue specificity from UniProt: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Subcellular UniProt: #Secreted
Recommended name: Interleukin-31
Gene name from HGNC: IL31 (IL-31)
AlphaFold DB: Q6EBC2
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q6EBC2
Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).
HPA link: https://www.proteinatlas.org/ENSG00000204671-IL31
Tissue specificity RNA from HPA: Not detected
Tissue expression from HPA: RNA-based expert annotation gave inconclusive results.
Single cell type specificity Cell type enriched (Early spermatids)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Secreted to blood
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000204671-IL31/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000204671-IL31/pathology/endometrial+cancer
OMIM: 609509
OMIM link2: https://www.omim.org/entry/609509
HGNC ID: HGNC:19372
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19372
