Biomarker: Fzd2

Histology type: endometrial carcinoma

Country: China

Region: Shanghai

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 13

Subgroup 2 name: para-tumor normal endometrial tissues

Subgroup 2 number: 13

Conclusion: Fzd2 may be a potential marker for EC metastasis and a target for future therapies for this disease.

Sample type : tissue

Sample method: Western blot

Expression pattern : expression

Funtion description: Fzd2 overexpression promoted the EMT phenotype, and these effects involved the activation of the Wnt/β-catenin pathway.

Funtion Uniprot: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues1 Publication (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286).

UniProt ID: Q14332

UniProt Link: https://www.uniprot.org/uniprotkb/Q14332/entry

Biological function from UniProt: #Wnt signaling pathway

Molecular function from UniProt:

Tissue specificity from UniProt: Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Frizzled-2

Gene name from HGNC: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

HPA class: Cancer-related genes Disease related genes G-protein coupled receptors Human disease related genes Potential drug targets

AlphaFold DB: Q14332

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q14332

HPA link: https://www.proteinatlas.org/ENSG00000180340-FZD2

Tissue specificity RNA from HPA: Tissue enhanced (choroid plexus)

Tissue expression from HPA: Cytoplasmic and membranous expression in several tissues.

Single cell type specificity Cell type enhanced (Leydig cells, Alveolar cells type 1, Peritubular cells, Kupffer cells)

Immune cell specificity: Immune cell enhanced (myeloid DC, classical monocyte)

Subcellular summary HPA Located in Nucleoplasm, Nuclear bodies, Cell Junctions

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000180340-FZD2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000180340-FZD2/pathology/endometrial+cancer

Phenotype ID: 164745

Disease: Omodysplasia 2 (OMOD2);Robinow syndrome-like features;

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 600667

OMIM link1: https://www.omim.org/entry/164745

OMIM link2: https://www.omim.org/entry/600667

HGNC ID: HGNC:4040

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4040