Biomarker: S100P

Histology type: rare type

Country: China

Region: Zhejiang

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 31

Subgroup 2 name: normal endometrial tissues

Subgroup 2 number: 28

Conclusion: S100P might be a specific biomarker and a potential drug target for squamous cell and adenosquamous carcinoma subtypes of endometrial cancer.S100P expression in EC could serve as a marker for histology and an indicator for prognosis and suitable therapies.

Sample type : tissue

Sample method: Immunohistochemistry/RT-PCR

Expression pattern : overexpressed

Funtion description: Elevated S100P promotes HEC-1A cell proliferation, migration, and invasion, and protected cells from natural and CDDPinduced cell apoptosis

Funtion Uniprot: May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).

UniProt ID: P25815

UniProt Link: https://www.uniprot.org/uniprotkb/P25815/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.

Subcellular UniProt: #Cell membrane #Cell projection #Cytoplasm #Membrane #Nucleus

Alternative name from UniProt:

Miscellaneous: This protein binds two calcium ions.

Recommended name: Protein S100-P

Gene name from HGNC: S100P

HPA class: Cytoplasmic and nuclear expression mainly in bone marrow, placenta and glandular epithelia in several tissues, including stomach and urinary bladder.

AlphaFold DB: P25815

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P25815

HPA link: https://www.proteinatlas.org/ENSG00000163993-S100P

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, stomach, urinary bladder)

Tissue expression from HPA: Cytoplasmic and nuclear expression mainly in bone marrow, placenta and glandular epithelia in several tissues, including stomach and urinary bladder.

Single cell type specificity Cell type enhanced (Urothelial cells, Syncytiotrophoblasts, Gastric mucus-secreting cells, Club cells)

Immune cell specificity: Group enriched (neutrophil, basophil, eosinophil)

Subcellular summary HPA Located in Nucleoplasm (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000163993-S100P/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000163993-S100P/pathology/endometrial+cancer

OMIM: 600614

OMIM link2: https://www.omim.org/entry/600614

HGNC ID: HGNC:10504

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10504